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| © UNICEF/NYHQ2009-0604/Noorani |
Multiple supplementation
Iron
Vitamin A
Iodine
Vitamin C
Niacine
Thiamin
Riboflavin
Zinc
Deficiencies of micronutrients are a major global health problem with many people living in low income countries deficient in key vitamins and minerals, particularly vitamin A, iodine, iron and zinc. Deficiencies occur when people do not have access to micronutrient-rich foods such as fruit, vegetables, animal products and fortified foods and increase the general risk of infectious illness and of dying from diarrhoea, measles, malaria and pneumonia. The groups most vulnerable to micronutrient deficiencies are pregnant women, lactating women and young children, mainly because they have a relatively greater need for vitamins and minerals and are more susceptible to the harmful consequences of deficiencies.
Micronutrient deficiencies can easily develop during an emergency or be made worse if they are already present. This happens because livelihoods and food crops are lost; food supplies are interrupted; diarrhoeal diseases break out, resulting in malabsorption and nutrient losses; and infectious diseases suppress the appetite whilst increasing the need for micronutrients to help fight illness. For these reasons it is essential to ensure that the micronutrient needs of people affected by a disaster are adequately met.
Multiple Micronutrient supplementation
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Joint Statement by WHO, WFP & UNICEF: Preventing and controlling micronutrient deficiencies in populations affected by an emergency [pdf] Joint Statement by the Micronutrient Initiative, International Nutrition Foundation and the Sprinkles Global Health Initiative at Sick Kids [pdf] |
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Guideline: Use of multiple micronutrient powders for home fortification of foods consumed by infants and children 6-23 months of age |
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Indicators and Methods for Cross-Sectional Surveys of Vitamin and Mineral Status of Populations | |
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Assessing Micronutrient Deficiencies in Emergencies, Current Practice and Future Directions, 2007 [pdf] |
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Use of Lipid-based Nutrient Supplements (LNS) to Improve the Nutrient Adequacy of General Food Distribution Rations for Vulnerable Sub-groups in Emergency Settings [zip] |
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Investing in the Future: A United Call to Action on Vitamin and Mineral Deficiencies (2009) |
Iron
Lack of iron eventually results in iron-deficiency anaemia. Typical signs are: paleness, tiredness, headaches and breathlessness.
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Oral iron supplements for children in malaria-endemic areas, Cochrane Review, 2011 [pdf] |
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Assessing the Iron Status of Populations, 2004 WHO & CDC Technical Consultation | |
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Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia, INACG, WHO & UNICEF, 1998 |
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Overview of Efficacy, Effectiveness and Safety of Micronutrient Powders [pdf] |
Vitamin A
Lack of vitamin A results in xeropthalmia. The signs in order of presentation are: night (xeropthalmia) blindness, Bitots spots (dryness and foamy accumulations on the inner eyelids), corneal xerosis (dullness or clouding of the cornea), keratomalacia (softening and ulceration of the cornea), permanent blindness.
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Guideline: Vitamin A Supplementation These guidelines are produced by WHO and available for the following groups:
Chinese & Russian are also available from the Nutrition Publications section of the WHO website. | |
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How to Add Deworming to Vitamin A Distribution, WHO & UNICEF, 2004 [pdf] |
Iodine
Iodine deficiency causes a range of abnormalities including goitre (swelling of the (goitre and cretinism) thyroid gland in the neck) and cretinism (mental and physical disability).
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Assessment of Iodine Deficiency Disorders and Monitoring their Elimination, A Guide for Programme Managers, WHO, UNICEF and ICCIDD, 2007 | |
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Recommended Iodine Levels in Salt and Guidelines for Monitoring their Adequacy and Effectiveness, WHO, UNICEF and ICCIDD, 1996 |
Vitamin C
Vitamin C deficiency results in scurvy. Typical signs are: swollen and bleeding gums, (scurvy) minute haemorrhages (bleeding), brittle hair, slow healing of wounds.
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Scurvy and its prevention and control in major emergencies, WHO 1999 [pdf] |
Niacin
Niacin deficiency results in pellagra, which affects the skin, gastro-intestinal tract and (pellagra) nervous systems. For this reason, it is sometimes called the 3Ds: dermatitis, diarrhoea and dementia. Dermatitis is the most distinctive feature causing redness and itching on areas of the skin exposed to sunlight.
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Pellagra and its prevention and control in major emergencies, WHO 2000 [pdf] |
Thiamin
Thiamin deficiency results in beriberi of which there are eight clinically (beriberi) recognizable syndromes.
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Thiamine deficiency and its prevention and control in major emergencies, WHO 1999 [pdf] |
Riboflavin
Riboflavin deficiency leads to ariboflavinosis, a deficiency disease characterised by angular stomatitis that affects the corners of the mouth, which can become split or cracked. Cheilosis, scaling and cracking of the surface of the lips may be seen. Glossitis, inflammation or swelling of the tongue is also sometimes reported.
Zinc
Zinc is essential for the normal growth and development of children and is naturally found in the diet, mainly in foods of animal origin. Dietary deficiency of zinc can lead to an increased risk of gastrointestinal infections and impaired gastrointestinal and immune function, including diarrhoea.
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WHO/UNICEF joint statement. Clinical management of acute diarrhoea. [pdf] | |
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Zinc supplementation in the management of diarrhea | |
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Related tools, guidelines & resources
NiE Toolkit, Section 5.3 and Section 5.4
HTP Module 4 - Micronutrient Malnutrition
HTP Module 14 - Micronutrient Interventions
Nutrition in Emergencies e-learning, Section 4 - Micronutrients
SPHERE Project Minimum Standards for Management of acute malnutrition and micronutrient deficiencies
Emergency Field Handbook - A guide for UNICEF Staff [PDF], (or also called Core Commitments for Children in Emergencies: Health and Nutrition) Health and Nutrition Chapter, section 21. Fortified Foods and multi-micronutrient supplements: An overview (p.109-115)
Related links

Electronic Library of Evidence for Nutrition Actions - Nutrients
WHO Publications Library for Micronutrients
Hellen Keller International (HKI)
Global Alliance for Improved Nutrition (GAIN)
The Micronutrients Database of VMNIS (WHO) contains information on anemia, vitamin A deficiency, and iodine deficiency in populations around the world.