In 2005, avian influenza (H5N1) emerged as a global concern because of its actual impact on poultry and livelihoods losses, and potential as the cause of a human influenza pandemic. The United Nations System was mobilized and encouraged to work in support of affected countries, address the global risk and prepare for a pandemic. Following the summit meeting with ASEAN Heads of State on 13 September 2005 at New York, the UN Secretary General appointed a UN System Senior Influenza Co-ordinator responsible for multi-lateral action.